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Article

Structure-function relationship of inhibitory Smads: Structural flexibility contributes to functional divergence.

Proteins - 1 Jun 2008

Hariharan Ramkumar, Pillai M Radhakrishna

Abstract excerpt

Smads are a small family of eukaryotic transcription regulators that play key roles in the transforming growth factor-beta signaling cascade. Smad6 and Smad7, the inhibitory or I-Smads, inhibit signaling downstream of TGF-beta type I receptors, thereby acting as negative regulators of signaling mediated by TGF-beta superfamily of ligands. Smad6 is known to specifically inhibit BMP type I receptor mediated...

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PMID: 18175316
DOI: 10.1002/prot.21869

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