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Article

Mutations in protein-binding hot-spots on the hub protein Smad3 differentially affect its protein interactions and Smad3-regulated gene expression.

PloS one - 1 Jan 2011

Schiro Michelle M, Stauber Sara E, Peterson Tami L, Krueger Chateen, Darnell Steven J, Satyshur Kenneth A, Drinkwater Norman R, Newton Michael A, Hoffmann F Michael

Abstract excerpt

BACKGROUND: Hub proteins are connected through binding interactions to many other proteins. Smad3, a mediator of signal transduction induced by transforming growth factor beta (TGF-β), serves as a hub protein for over 50 protein-protein interactions. Different cellular responses mediated by Smad3 are the product of cell-type and context dependent Smad3-nucleated protein complexes acting in concert. Our hypothesis...

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Identifiers

PMID: 21949838
DOI: 10.1371/journal.pone.0025021
PMCID: PMC3176292

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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