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Article

Suppression of TGF-β/SMAD signaling by an inner nuclear membrane phosphatase complex

2024-09-23

Abstract excerpt

Cytokines of the TGF-β superfamily control essential cell fate decisions via receptor regulated SMAD (R-SMAD) transcription factors. Ligand-induced R-SMAD phosphorylation in the cytosol triggers their activation and nuclear accumulation. We determined how R-SMADs are inactivated by dephosphorylation in the cell nucleus to counteract signaling by TGF-β superfamily ligands. We showed that R-SMAD dephosphorylation is...

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Identifiers and source

Literature Corpus work
c60966c0-dd47-53ce-a9a7-594b9c29d66a
DOI
10.1101/2024.09.23.614427
Open publication

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Suppression of TGF-β/SMAD signaling by an inner nuclear membrane phosphatase complexDOI 10.1101/2024.09.23.614427
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