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Article

Structural determinants of Smad function in TGF-β signaling.

Trends in biochemical sciences - 1 Jun 2015

Macias Maria J, Martin-Malpartida Pau, Massagué Joan

Abstract excerpt

Smad transcription factors are central to the signal transduction pathway that mediates the numerous effects of the transforming growth factor β (TGF-β) superfamily of cytokines in metazoan embryo development as well as in adult tissue regeneration and homeostasis. Although Smad proteins are conserved, recent genome-sequencing projects have revealed their sequence variation in metazoan evolution, human...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25935112
DOI: 10.1016/j.tibs.2015.03.012
PMCID: PMC4485443

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