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Article

Structural basis of Smad2 recognition by the Smad anchor for receptor activation.

Science (New York, N.Y.) - 7 Jan 2000

Wu G, Chen Y G, Ozdamar B, Gyuricza C A, Chong P A, Wrana J L, Massagué J, Shi Y

Abstract excerpt

The Smad proteins mediate transforming growth factor-beta (TGFbeta) signaling from the transmembrane serine-threonine receptor kinases to the nucleus. The Smad anchor for receptor activation (SARA) recruits Smad2 to the TGFbeta receptors for phosphorylation. The crystal structure of a Smad2 MH2 domain in complex with the Smad-binding domain (SBD) of SARA has been determined at 2.2 angstrom resolution. SARA SBD,...

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Share to Activin Receptors, Type I
Share to Crystallography, X-Ray

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hydrogen Bonding

Share to Protein Structure, Secondary

Share to Receptor, Transforming Growth Factor-beta Type I

Share to Receptors, Transforming Growth Factor beta

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Source

Identifiers

PMID: 10615055
DOI: 10.1126/science.287.5450.92

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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