Article
Crystal structure of a Smad MH1 domain bound to DNA: insights on DNA binding in TGF-beta signaling.
Cell - 4 Sept 1998
Shi Y, Wang Y F, Jayaraman L, Yang H, Massagué J, Pavletich N P
Abstract excerpt
The Smad family of proteins, which are frequently targeted by tumorigenic mutations in cancer, mediate TGF-beta signaling from cell membrane to nucleus. The crystal structure of a Smad3 MH1 domain bound to an optimal DNA sequence determined at 2.8 A resolution reveals a novel DNA-binding motif. I...
Topics
- Amino Acid Sequence
- Binding Sites
- Cell Transformation, Neoplastic
- Crystallization
- Crystallography, X-Ray
- DNA
- DNA-Binding Proteins
- Humans
- Models, Molecular
- Molecular Sequence Data
- Mutation
- Peptide Fragments
- Protein Structure, Secondary
- Protein Structure, Tertiary
- Signal Transduction
- Smad3 Protein
- Trans-Activators
- Transforming Growth Factor beta