Article

Lineage-Specific Silencing of <i>PSAT1</i> Induces Serine Auxotrophy and Sensitivity to Dietary Serine Starvation in Luminal Breast Tumors

2020-06-20

Abstract excerpt

<h4>SUMMARY</h4> A major challenge of targeting metabolism for cancer therapy is pathway redundancy, where multiple sources of critical nutrients can limit the effectiveness of some metabolism-targeted therapies. Here, we analyzed lineage-dependent gene expression in human breast tumors to identify differences in metabolic gene expression that may limit pathway redundancy and create therapeutic vulnerabilities. W...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d50e3246-66d8-51e7-bc47-1b53a91b57a7
DOI: 10.1101/2020.06.19.161844

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Lineage-Specific Silencing of <i>PSAT1</i> Induces Serine Auxotrophy and Sensitivity to Dietary Serine Starvation in Luminal Breast TumorsDOI 10.1101/2020.06.19.161844Read

Serine auxotrophy is a targetable vulnerability driven by PSAT1 suppression in AMLSemantic proximity Read

Linking Serine/Glycine Metabolism to Radiotherapy ResistanceSemantic proximity Read

Multifaceted role of serine hydroxymethyltransferase in health and diseaseSemantic proximity Read

Differential expression of enzymes associated with serine/glycine metabolism in different breast cancer subtypes.Semantic proximity Read

De novo serine biosynthesis from glucose predicts sex-specific response to antifolates in non-small cell lung cancer cell linesSemantic proximity Read

Mitochondrial SHMT2 is a crucial therapeutic target in dedifferentiated thyroid cancerSemantic proximity Read

Dietary Serine Deprivation Impacts H3K27 and H3K4 Methyl Epigenomes to Impede Head and Neck Cancer Cell Plasticity and Tumor GrowthSemantic proximity Read

Transcriptional Profiling Reveals a Common Metabolic Program in High-Risk Human Neuroblastoma and Mouse Neuroblastoma Sphere-Forming CellsSemantic proximity Read

Anaplastic Thyroid Cancer Cells Upregulate Mitochondrial One-Carbon Metabolism To Meet Purine Demand, Eliciting A Critical Targetable VulnerabilitySemantic proximity Read

PHGDH is a targetable driver of PDAC progressionSemantic proximity Read

Epigenetic reprogramming induced by key metabolite depletion is an evolutionarily ancient path to tumorigenesis.Semantic proximity Read

The m6A methyltransferase RBM15 drives the growth of triple-negative breast cancer cells through the stimulation of serine and glycine metabolismSemantic proximity Read