Article

Serine auxotrophy is a targetable vulnerability driven by PSAT1 suppression in AML

2025-05-14

Abstract excerpt

Serine metabolism is of growing biologic and therapeutic interest in cancer. Upregulation of the serine synthesis pathway (SSP) can fuel tumor growth, and cancers with this phenotype are often sensitive to SSP inhibitors. In parallel, dietary restriction of serine and glycine (SG) can suppress some cancers, but the determinants of sensitivity to this approach are poorly understood. This is especially true in acute...

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Literature Corpus work: 1ec5aa2e-ab21-5870-a924-e16a41dafa56
DOI: 10.1101/2025.05.13.651470

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