Article

Dietary Serine Deprivation Impacts H3K27 and H3K4 Methyl Epigenomes to Impede Head and Neck Cancer Cell Plasticity and Tumor Growth

2025-10-22

Abstract excerpt

<h4>ABSTRACT</h4> Oral squamous cell carcinoma (OSCC) is an aggressive head and neck malignancy characterized by high morbidity, therapeutic resistance and intratumoral heterogeneity driven by plastic cell states. Given that metabolic inputs can shape cell identities via epigenetic mechanisms, we investigated how metabolism of a non-essential amino acid, serine, affects histone modifications with key roles in cel...

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Literature Corpus work: 59d6c21e-a4cf-574c-88f2-a587f85c1c43
DOI: 10.1101/2025.10.21.683420

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Dietary Serine Deprivation Impacts H3K27 and H3K4 Methyl Epigenomes to Impede Head and Neck Cancer Cell Plasticity and Tumor GrowthDOI 10.1101/2025.10.21.683420Read

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