Article

The m6A methyltransferase RBM15 drives the growth of triple-negative breast cancer cells through the stimulation of serine and glycine metabolism

2023-07-25

Abstract excerpt

<title>Abstract</title> <italic>N</italic> 6 -adenosine methylation (m6A) is critical for controlling cancer cell growth and tumorigenesis. However, the function and detailed mechanism of how m6A methyltransferases modulate m6A levels on specific targets remains unknown. In the current study, we identified significantly elevated levels of RBM15, an m6A wr...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 489afd7f-6b5d-5dd3-ac76-b49c3f5ac955
DOI: 10.21203/rs.3.rs-3070549/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The m6A methyltransferase RBM15 drives the growth of triple-negative breast cancer cells through the stimulation of serine and glycine metabolismDOI 10.21203/rs.3.rs-3070549/v1Read

Analysis of N6-methyladenosine (m6A) methyltransferase reveals METTL14 and ZC3H13 as tumor suppressor genes in breast cancerSemantic proximity Read

Differential expression of enzymes associated with serine/glycine metabolism in different breast cancer subtypes.Semantic proximity Read

RBM15B Promotes Hepatocellular Carcinoma Progression via IGF2BP1-Mediated ITSN2 mRNA StabilizationSemantic proximity Read

RBM15 facilitates laryngeal squamous cell carcinoma progression by regulating TMBIM6 stability through IGF2BP3 dependentSemantic proximity Read

METTL3 regulates breast cancer-associated alternative splicing switchesSemantic proximity Read

MAT2A Localization and Its Independently Prognostic Relevance in Breast Cancer PatientsSemantic proximity Read

PHGDH activity in Triple-Negative Breast Cancer studies--A glimmer of hope in the midst of difficult treatment processSemantic proximity Read

Linking Serine/Glycine Metabolism to Radiotherapy ResistanceSemantic proximity Read

Lineage-Specific Silencing of PSAT1 Induces Serine Auxotrophy and Sensitivity to Dietary Serine Starvation in Luminal Breast TumorsSemantic proximity Read

Drivers of de novo Serine/Glycine synthesis in acute leukemia.Semantic proximity Read

Multifaceted role of serine hydroxymethyltransferase in health and diseaseSemantic proximity Read

Invasive lobular carcinoma integrated multi-omics analysis reveals silencing of Arginosuccinate synthase and upregulation of nucleotide biosynthesis in tamoxifen resistanceSemantic proximity Read