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Heterogeneity of human pancreatic β-cells

1 Sept 2019

Abstract excerpt

BACKGROUND: Human pancreatic β-cells are heterogeneous. This has been known for a long time and is based on various functional and morphological readouts. β-Cell heterogeneity could reflect fixed subpopulations with distinct functions. However, recent pseudotime analysis of large-scale RNA sequencing data suggest that human β-cell subpopulations may rather reflect dynamic interchangeable states characterized by...

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PMID: 31500834
DOI: 10.1016/j.molmet.2019.06.015

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