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Article

Evaluation of the binding interactions between Plasmodium falciparum Kelch-13 mutant recombinant proteins with artemisinin.

PloS one - 1 Jan 2024

Md Yusuf Noorazian, Azman Aisya Nazura, Abdul Aziz Amirul Adli, Ahmad Fuad Fazia Adyani, Nasarudin Ruhayatun Naimah, Hisam Shamilah

Abstract excerpt

Malaria, an ancient mosquito-borne illness caused by Plasmodium parasites, is mostly treated with Artemisinin Combination Therapy (ACT). However, Single Nucleotide Polymorphisms (SNPs) mutations in the P. falciparum Kelch 13 (PfK13) protein have been associated with artemisinin resistance (ART-R). Therefore, this study aims to generate PfK13 recombinant proteins incorporating of two specific SNPs mutations,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39146276
DOI: 10.1371/journal.pone.0306975
PMCID: PMC11326563

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