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Whole-genome sieve analysis: Identification of protective malaria antigens by leveraging allele-specific vaccine efficacy.

Vaccine - 19 Mar 2025

Scalsky Ryan, Dwivedi Ankit, Stabler Thomas C, Mbambo Gillian, Ouattara Amed, Lyke Kirsten E, Takala-Harrison Shannon, Silva Joana C

Abstract excerpt

Discovery of new protective malaria antigens will enable the development of novel vaccine formulations with potentially higher efficacy. While several high-throughput experimental approaches enable the identification of novel immunogens, none so far has been designed to selectively identify protective antigens. Here, we propose that sieve analysis conducted on the whole genome (SAWG) can be used specifically for...

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PMID: 39923546
DOI: 10.1016/j.vaccine.2025.126783

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