Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Reshaping antibody diversity.

Cell - 6 Jun 2013

Wang Feng, Ekiert Damian C, Ahmad Insha, Yu Wenli, Zhang Yong, Bazirgan Omar, Torkamani Ali, Raudsepp Terje, Mwangi Waithaka, Criscitiello Michael F, Wilson Ian A, Schultz Peter G, Smider Vaughn V

Abstract excerpt

Some species mount a robust antibody response despite having limited genome-encoded combinatorial diversity potential. Cows are unusual in having exceptionally long CDR H3 loops and few V regions, but the mechanism for creating diversity is not understood. Deep sequencing reveals that ultralong CDR H3s contain a remarkable complexity of cysteines, suggesting that disulfide-bonded minidomains may arise during...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Motifs
Share to Antibody Diversity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cattle

Share to Complementarity Determining Regions

Share to Crystallography, X-Ray

Share to Cysteine

Share to Immunoglobulin G

Share to Immunoglobulin M

Source

Open in PubMed Open full text

Identifiers

PMID: 23746848
DOI: 10.1016/j.cell.2013.04.049
PMCID: PMC4007204

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Reshaping antibody diversity.PMID 23746848Read ↗

Diversity in the Cow Ultralong CDR H3 Antibody Repertoire.Semantic proximity Read ↗

A Broad Role for Cysteines in Bovine Antibody DiversitySemantic proximity Read ↗

Structural and genetic diversity in antibody repertoires from diverse species.Semantic proximity Read ↗

Landscape of Non-canonical Cysteines in Human VH Repertoire Revealed by Immunogenetic AnalysisSemantic proximity Read ↗

High-Resolution Description of Antibody Heavy-Chain Repertoires in HumansSemantic proximity Read ↗

Mechanistic principles of an ultra-long bovine CDR reveal strategies for antibody designSemantic proximity Read ↗

Secondary mechanisms of diversification in the human antibody repertoireSemantic proximity Read ↗

Natural and man-made V-gene repertoires for antibody discoverySemantic proximity Read ↗

The evolutionary and structural 'logic' of antigen receptor diversity.Semantic proximity Read ↗

Conformational diversity facilitates antibody mutation trajectories and discrimination between foreign and self-antigens.Semantic proximity Read ↗

Transferring the Characteristics of Naturally Occurring and Biased Antibody Repertoires to Human Antibody Libraries by Trapping CDRH3 SequencesSemantic proximity Read ↗

Human antibody immune responses are personalized by selective removal of MHC-II peptide epitopesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.