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Article

Design of Broadly Cross-Reactive M Protein–Based Group A Streptococcal Vaccines

1 Aug 2021

Abstract excerpt

Group A streptococcal infections are a significant cause of global morbidity and mortality. A leading vaccine candidate is the surface M protein, a major virulence determinant and protective Ag. One obstacle to the development of M protein-based vaccines is the >200 different M types defined by the N-terminal sequences that contain protective epitopes. Despite sequence variability, M proteins share coiled-coil...

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PMID: 34341168
DOI: 10.4049/jimmunol.2100286

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