Article

Macropinocytosis of amyloid precursor protein requires the adaptor protein Fe65 and the recruitment and activity of Arf6 and the RhoGTPases Rac1, Cdc42 and RhoA

2025-03-10

Abstract excerpt

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by the buildup of the highly toxic peptide amyloid-beta (Aβ). Previously, we demonstrated that Aβ is generated from the cleavage of amyloid precursor protein (APP) after internalization to lysosomes via macropinocytosis. However, the regulation of APP micropinocytosis has remained uncharacterized. Evidence suggests that APP may func...

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Literature Corpus work: d4ec6fd5-4db7-5c41-95dd-d11b1bafaae5
DOI: 10.1101/2025.03.02.641070

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