Article
SOD1 protein aggregates stimulate macropinocytosis in neurons to facilitate their propagation.
Molecular neurodegeneration - 31 Oct 2015
Zeineddine Rafaa, Pundavela Jay F, Corcoran Lisa, Stewart Elise M, Do-Ha Dzung, Bax Monique, Guillemin Gilles, Vine Kara L, Hatters Danny M, Ecroyd Heath, Dobson Christopher M, Turner Bradley J, Ooi Lezanne, Wilson Mark R, Cashman Neil R, Yerbury Justin J
Abstract excerpt
BACKGROUND: Amyotrophic Lateral Sclerosis is characterized by a focal onset of symptoms followed by a progressive spread of pathology that has been likened to transmission of infectious prions. Cell-to-cell transmission of SOD1 protein aggregates is dependent on fluid-phase endocytosis pathways, although the precise molecular mechanisms remain to be elucidated. RESULTS: We demonstrate in this paper that SOD1...
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