Article

The recycling endosome biogenesis machinery coordinates BACE1 endosomal sorting and amyloid-β production

2023-04-06

Abstract excerpt

Alzheimer’s disease (AD) is the most common form of dementia worldwide. One of AD’s main pathological hallmarks is the cerebral plaque deposits of β-amyloid (Aβ). Aβ is generated through sequential enzymatic cleavage of the amyloid precursor protein (APP). The β-secretase or β-site APP-cleaving enzyme 1 (BACE1) initiates this cleavage and is thus key to regulate Aβ formation. Both APP and BACE1 transit through the...

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Literature Corpus work: 2d7e6d01-7a77-5a13-b7ba-1fd4a8173870
DOI: 10.1101/2023.04.05.535676

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