Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Zinc Finger Ran-Binding Protein 3 (ZRANB3): An Advanced Perspective.

International journal of molecular sciences - 6 Jan 2026

Pelucchi Paride, Mosca Ettore, Tomsič Nika, Waheed Yossma, Tigani Wendalina, Chiodi Alice, Mojumdar Aditya, Gerdol Marco, De March Matteo

Abstract excerpt

Human zinc finger Ran-binding protein 3 (ZRANB3) is crucial for DNA damage tolerance (DDT), as it prevents excessive damage, restores fork progression, and ultimately maintains genome stability. This unique and ancient architecture mainly exerts its function during replication fork reversal (RFR) and within the p53/Polι axis; thus, ZRANB3 is considered a tumour suppressor. However, possible additional roles in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Damage
Share to DNA Replication

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DDT gene

Share to Gene Expression Regulation, Neoplastic

Share to Mutation

Share to Neoplasms

Share to Tumor Suppressor Protein p53

Source

Open in PubMed Open full text

Identifiers

PMID: 41596226
DOI: 10.3390/ijms27020574
PMCID: PMC12841045

Genes

ZRANB3
DDT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 20 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Zinc Finger Ran-Binding Protein 3 (ZRANB3): An Advanced Perspective.PMID 41596226Read ↗

RNA-Binding Motif Protein 3 as a Therapeutic and Prognostic Target for Drug DiscoverySemantic proximity Read ↗

MATR3’s Role beyond the Nuclear Matrix: From Gene Regulation to Its Implications in Amyotrophic Lateral Sclerosis and Other DiseasesSemantic proximity Read ↗

ZNF423: Transcriptional modulation in development and cancerSemantic proximity Read ↗

E3 ligases: a ubiquitous link between DNA repair, DNA replication and human diseaseSemantic proximity Read ↗

Bromodomain 4: a cellular Swiss army knifeSemantic proximity Read ↗

Selective targeting of TBXT with DARPins identifies regulatory networks and therapeutic vulnerabilities in chordomaSemantic proximity Read ↗

Functions of SMARCAL1, ZRANB3, and HLTF in maintaining genome stability.Semantic proximity Read ↗

Role of RBMS3 Novel Potential Regulator of the EMT Phenomenon in Physiological and Pathological ProcessesSemantic proximity Read ↗

Zinc finger proteins: guardians of genome stabilitySemantic proximity Read ↗

The Chromatin Remodeler ATRX: Role and Mechanism in Biology and CancerSemantic proximity Read ↗

An overexpression platform reveals the functional diversity of human KRAB-Zinc Finger Proteins in maintaining cellular homeostasisSemantic proximity Read ↗

Nuclear TARBP2 drives oncogenic dysregulation of RNA splicing and decaySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.