Article
The Zinc Finger Ran-Binding Protein 3 (ZRANB3): An Advanced Perspective.
International journal of molecular sciences - 6 Jan 2026
Pelucchi Paride, Mosca Ettore, Tomsič Nika, Waheed Yossma, Tigani Wendalina, Chiodi Alice, Mojumdar Aditya, Gerdol Marco, De March Matteo
Abstract excerpt
Human zinc finger Ran-binding protein 3 (ZRANB3) is crucial for DNA damage tolerance (DDT), as it prevents excessive damage, restores fork progression, and ultimately maintains genome stability. This unique and ancient architecture mainly exerts its function during replication fork reversal (RFR) and within the p53/Polι axis; thus, ZRANB3 is considered a tumour suppressor. However, possible additional roles in...
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