Article

The role of accelerated growth plate fusion in the absence of SOCS2 on osteoarthritis vulnerability

2021-05-15

Abstract excerpt

Osteoarthritis is the most prevalent systemic musculoskeletal disorder characterised by articular cartilage degeneration and subchondral bone (SCB) sclerosis. Here we sought to examine the contribution of accelerated growth to osteoarthritis development using a murine model of excessive longitudinal growth. Suppressor of cytokine signalling 2 (SOCS2) is a negative regulator of growth hormone (GH) signalling, thus...

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Literature Corpus work: d4ba34f7-a77f-5bd3-936c-2c89bcb1f470
DOI: 10.1101/2021.05.13.444074

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