Article

SHIP2 deletion in cartilage does not modulate osteoarthritis in a post-traumatic mouse model

2026-05-07

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Objectives</h4> The inositol phosphatase SHIP2 plays a crucial role in skeletal development and chondrocyte differentiation, and mutations in INPPL1 (encoding SHIP2) cause opsismodysplasia, a chondrodysplasia with marked cartilage abnormalities. We investigated whether SHIP2 contributes to structural joint remodeling in osteoarthritis (OA). <h4>Methods</h4> A cartilage-specific condition...

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Literature Corpus work: b261fc7f-b28e-5fa5-89c8-91a612a65dbd
DOI: 10.64898/2026.05.04.722576

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