Article
Phenotypic characterization of Slc26a2 mutant mice reveals a multifactorial etiology of spondylolysis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jan 2020
Zheng Chao, Lin Xisheng, Liu He, Lu Weiguang, Xu Xiaolong, Wang Di, Gao Bo, Wang Cheng, Zhou Jinru, Fan Jing, Hu Yaqian, Jie Qiang, Chen Di, Yang Liu, Luo Zhuojing
Abstract excerpt
Confusion persists over pathogenesis of spondylolysis. To confirm pathogenicity of the previously identified causative mutation of spondylolysis and investigate the genetic etiology, we generate a new mouse line harboring D673V mutation in the Slc26a2 gene. D673V mutation induces delayed endochondral ossification characterized by transiently reduced chondrocyte proliferation in mice at the early postnatal stage....
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