Article

Trade-Offs Between Antibacterial Resistance and Fitness Cost in the Production of Metallo-β-Lactamase by Enteric Bacteria Manifest as Sporadic Emergence of Carbapenem Resistance in a Clinical Setting

2020-10-25

Abstract excerpt

Meropenem is a clinically important antibacterial reserved for treatment of multi-resistant infections. In meropenem-resistant bacteria of the family Enterobacteriales, NDM-1 is considerably more common than IMP-1, despite both metallo-β-lactamases (MBLs) hydrolysing meropenem with almost identical kinetics. We show that bla NDM-1 consistently confers meropenem resistance in wild-type Enterobacteriales, but bla...

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Literature Corpus work: d49dc61f-b63c-52cd-b39c-30fab45586be
DOI: 10.1101/2020.10.24.353581

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Trade-Offs Between Antibacterial Resistance and Fitness Cost in the Production of Metallo-β-Lactamase by Enteric Bacteria Manifest as Sporadic Emergence of Carbapenem Resistance in a Clinical SettingDOI 10.1101/2020.10.24.353581Read

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