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Article

Porin deficiency or plasmid copy number increase mediated carbapenem-resistant Escherichia coli resistance evolution.

Emerging microbes & infections - 1 Dec 2024

Xiang Guoxiu, Zhao Zhiwei, Zhang Shebin, Cai Yimei, He Yuting, Zeng Jianming, Chen Cha, Huang Bin

Abstract excerpt

This study investigated resistance evolution mechanisms of conjugated plasmids and bacterial hosts under different concentrations of antibiotic pressure. Ancestral strain ECNX52 was constructed by introducing the blaNDM-5-carrying IncX3 plasmid into E. coli C600, and was subjected to laboratory evolution under different concentrations of meropenem pressure. Minimal inhibitory concentrations and conjugation...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38712634
DOI: 10.1080/22221751.2024.2352432
PMCID: PMC11107853

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