Article

The fitness cost of metallo-β-lactamase expression is a potential target for new therapeutic approaches to carbapenem resistance

2023-12-22

Abstract excerpt

<title>Abstract</title> <p>Carbapenem antibiotics represent the most reliable last-resort treatment for bacterial infections. The widespread acquisition of metallo-β-lactamases (MBLs), such as VIM-2, is a significant contributor to the emergence of carbapenem-resistant pathogens. The absence of clinically available MBL inhibitors necessitates the development of new approaches to treat carbapenem-resistant infecti...

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Literature Corpus work: 5f92d4a3-4257-54ea-bdfe-dbe0cf964c66
DOI: 10.21203/rs.3.rs-3683698/v1

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