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Article

Fitness trade-offs in blaTEM evolution.

Antimicrobial agents and chemotherapy - 1 Jul 2008

Mroczkowska Joanna E, Barlow Miriam

Abstract excerpt

bla(TEM-1) expression results in penicillin resistance, whereas expression of many bla(TEM-1) descendants, called extended-spectrum beta-lactamases (ESBLs), results simultaneously in resistance to penicillins and extended-spectrum cephalosporins. Despite the expanded resistance phenotypes conferred by many ESBLs, bla(TEM-1) is still the most abundant bla(TEM) allele in many microbial populations. This study...

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Identifiers

PMID: 18443128
DOI: 10.1128/AAC.00018-08
PMCID: PMC2443931

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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