Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Promoter regulatory mode evolution enhances the high multidrug resistance of tmexCD1-toprJ1

2 Apr 2024

Abstract excerpt

ABSTRACT Antibiotic resistance could rapidly emerge from acquiring the mobile antibiotic resistance genes, which are commonly evolved from an intrinsic gene. The emergence of the plasmid-borne mobilized efflux pump gene cluster tmexCD1-toprJ1 renders the last-resort antibiotic tigecycline ineffective, although its evolutionary mechanism remains unclear. In this study, we investigate the regulatory mechanisms of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibiotic Resistance in Bacteria
Share to Antibiotics Pharmacokinetics and Efficacy
Share to Pharmaceutical and Antibiotic Environmental Impacts

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38564664
DOI: 10.1128/mbio.00218-24

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Promoter regulatory mode evolution enhances the high multidrug resistance of tmexCD1-toprJ1PMID 38564664Read ↗

Emergence and dissemination of multidrug-resistant Klebsiella pneumoniae harboring the novel tmexCD-toprJ RND efflux pump operonSemantic proximity Read ↗

Dissemination of the mobilised RND efflux pump gene cluster tmexCD-toprJ among Klebsiella pneumoniaeSemantic proximity Read ↗

Emergence of a novel mobile RND-type efflux pump gene cluster, <i>tmexC3D2-toprJ1b</i> , in <i>Pseudomonas</i> speciesSemantic proximity Read ↗

Genome recombination-mediated tRNA up-regulation conducts general antibiotic resistance of bacteria at early stageSemantic proximity Read ↗

Emergence of a plasmid-borne tigecycline resistance in Klebsiella pneumoniae in VietnamSemantic proximity Read ↗

Characterization of IncHI1B Plasmids Encoding Efflux Pump TmexCD2-ToprJ2 in Carbapenem-Resistant Klebsiella variicola, Klebsiella quasipneumoniae, and Klebsiella michiganensis StrainsSemantic proximity Read ↗

Modulation of rob expression accelerates development of antibiotic resistance in Yersinia enterocolitica.Semantic proximity Read ↗

A transferable IncC-IncX3 hybrid plasmid co-carrying <i>bla</i> <sub>NDM-4</sub> , <i>tet</i> (X4), and <i>tmexCD3-toprJ3</i> confers resistance to carbapenem and tigecyclineSemantic proximity Read ↗

Two novel trimethoprim resistance genes, dfra50 and dfra51 , identified in phage-plasmidsSemantic proximity Read ↗

Mechanistic Insights into Crosstalk of Tet(X) and MCR-1, Two Resistance Enzymes Co-produced by A Single PlasmidSemantic proximity Read ↗

Mobilization of antibiotic resistance genes differ by resistance mechanismSemantic proximity Read ↗

Rethinking the Primary Functions of the “Tellurium Resistance Genes”Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.