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Article

Assessment of the reversibility of resistance in the absence of antibiotics and its relationship with the resistance gene's fitness cost: a genetic study with mcr-1.

The Lancet. Microbe - 1 Aug 2024

Guo Ziyan, Feng Siyuan, Liang Lujie, Wu Zhuoxing, Min Lulu, Wang Ruizhi, Li Jiachen, Zhong Lan-Lan, Zhao Hui, Chen Xiaoshu, Tian Guo-Bao, Yang Jian-Rong

Abstract excerpt

BACKGROUND: The intensive use of antibiotics has resulted in strong natural selection for the evolution of antimicrobial resistance (AMR), but whether, and under what circumstances, the removal of antibiotics would result in a rapid reduction in AMR has been insufficiently explored. We aimed to test the hypothesis that in the simple, yet common, case of AMR conferred by a single gene, removing antibiotics would...

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PMID: 38870982
DOI: 10.1016/S2666-5247(24)00052-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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