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Article

Pathogen-host adhesion between SARS-CoV-2 spike proteins from different variants and human ACE2 studied at single-molecule and single-cell levels.

Emerging microbes & infections - 1 Dec 2022

Zhang Xiaoxu, Hong Bixia, Wei Peng, Pei Pengfei, Xu Haifeng, Chen Long, Tong Yigang, Chen Jialin, Luo Shi-Zhong, Fan Huahao, He Chengzhi

Abstract excerpt

The binding of the receptor binding domain (RBD) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein onto human angiotensin-converting enzyme 2 (ACE2) is considered as the first step for the virus to adhere onto the host cells during the infection. Here, we investigated the adhesion of spike proteins from different variants and ACE2 using single-molecule and single-cell force...

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Source

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Identifiers

PMID: 36153659
DOI: 10.1080/22221751.2022.2128887
PMCID: PMC9639500

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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