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Force-tuned avidity of spike variant-ACE2 interactions viewed on the single-molecule level

24 Dec 2022

Abstract excerpt

Recent waves of COVID-19 correlate with the emergence of the Delta and the Omicron variant. We report that the Spike trimer acts as a highly dynamic molecular caliper, thereby forming up to three tight bonds through its RBDs with ACE2 expressed on the cell surface. The Spike of both Delta and Omicron (B.1.1.529) Variant enhance and markedly prolong viral attachment to the host cell receptor ACE2, as opposed to...

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Share to Advanced biosensing and bioanalysis techniques
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PMID: 36566234
DOI: 10.1038/s41467-022-35641-3

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