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Article

A comparative nanomechanical study of antibody and nanobody binding to SARS-CoV-2 variants.

Physical chemistry chemical physics : PCCP - 22 Apr 2026

Cofas-Vargas Luis F, Olivos-Ramirez Gustavo E, Marrink Siewert J, Poma Adolfo B

Abstract excerpt

The receptor-binding domain (RBD) of the SARS-CoV-2 spike protein is the main target of neutralizing antibodies (Abs) and nanobodies (Nbs). Although their binding affinities are well characterized, their mechanical stability under force remains poorly understood, despite its relevance in viral attachment, immune recognition, and receptor engagement. Here, we present a comparative nanomechanical analysis of three...

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Share to Antibodies, Neutralizing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41885290
DOI: 10.1039/d6cp00556j

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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