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Article

N501Y mutation of spike protein in SARS-CoV-2 strengthens its binding to receptor ACE2.

eLife - 20 Aug 2021

Tian Fang, Tong Bei, Sun Liang, Shi Shengchao, Zheng Bin, Wang Zibin, Dong Xianchi, Zheng Peng

Abstract excerpt

SARS-CoV-2 has been spreading around the world for the past year. Recently, several variants such as B.1.1.7 (alpha), B.1.351 (beta), and P.1 (gamma), which share a key mutation N501Y on the receptor-binding domain (RBD), appear to be more infectious to humans. To understand the underlying mechanism, we used a cell surface-binding assay, a kinetics study, a single-molecule technique, and a computational method to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Lipid Membrane Structure and Behavior

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Share to Spike Glycoprotein, Coronavirus

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Identifiers

PMID: 34414884
DOI: 10.7554/eLife.69091
PMCID: PMC8455130

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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