Gating interactions steer loop conformational changes in the active site of the L1 metallo-β-lactamase

Abstract excerpt

β-lactam antibiotics are the most important and widely used antibacterial agents across the world. However, the widespread dissemination of β-lactamases among pathogenic bacteria limits the efficacy of β-lactam antibiotics. This has created a major public health crisis. The use of β-lactamase inhibitors has proven useful in restoring the activity of β-lactam antibiotics, yet, effective clinically approved inhibito...

Topics

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• beta-Lactamases
• Catalytic Domain
• Computational Drug Discovery Methods
• Hydrogen Bonding
• Molecular Dynamics Simulation
• Mutation
• Protein Conformation
• Pseudomonas aeruginosa

Identifiers and source

Literature Corpus work

d47a395b-ba1a-52eb-a6e2-d32f7bfe1913

DOI

10.1101/2022.10.25.513716