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Article

Structural and functional characterization of an active site-influencing variant (IMP-1-F218Y) in IMP-1 metallo-β-lactamase.

The FEBS journal - 1 Aug 2026

Baidya Subhecchha, Dhankhar Kunal, Karan Riya, Hazra Mousumi, Adhikary Rajsekhar, Sen Tanmoy, Hazra Saugata

Abstract excerpt

Antimicrobial resistance (AMR) has become a critical global health challenge, largely driven by metallo-β-lactamase (MBL)-mediated hydrolysis of β-lactam antibiotics, which remain the cornerstone of modern antimicrobial therapy. IMP-1, an MBL first identified in Japan, exhibits potent carbapenemase activity and currently lacks effective clinical inhibitors. To explore how distal mutations modulate catalytic...

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PMID: 41870155
DOI: 10.1111/febs.70474
PMCID: PMC13440610

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 11 Sept 2026.

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