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Article

Inhibitor-Dependent Tolerance of New Delhi Metallo-β-Lactamase Driven by Single Mutation-Induced Conformational Changes.

Journal of the American Chemical Society - 30 Jul 2025

Huang Liwen, Wong Tsz-Fung, Cheng Qipeng, So Pui-Kin, Liu Ming, Li Xuechen, Chen Sheng, Yao Zhong-Ping

Abstract excerpt

The emergence of metallo-β-lactamases as formidable adversaries in the antimicrobial resistance crisis stems from their unparalleled capacity to hydrolyze β-lactam antibiotics. This study deciphers the evolutionary strategy of New Delhi metallo-β-lactamase (NDM) variants through studies of conformational dynamics. We employ hydrogen/deuterium exchange mass spectrometry (HDX-MS) to map conformational landscapes of...

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Identifiers

PMID: 40690763
DOI: 10.1021/jacs.5c05669

Genes

HDX
ASL

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