Article

Dynamic Differences in Clinically relevant Pen β-Lactamases from Burkholderia spp.

2024-11-03

Abstract excerpt

Antimicrobial resistance (AMR) is a global threat, with Burkholderia species contributing significantly to difficult-to-treat infections. Ambler Class A Pen β-lactamases are produced by all Burkholderia spp., and their mutation or overproduction leads to the resistance of β-lactam antibiotics. In this study we investigate the dynamic differences between four clinically relevant Pen β-lactamases (PenA, PenI, PenL a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9cbb816d-8f07-58bc-95e3-c059204081a3
DOI: 10.1101/2024.11.02.621643

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Dynamic Differences in Clinically relevant Pen β-Lactamases from Burkholderia spp.DOI 10.1101/2024.11.02.621643Read

Insights into β-lactamases from Burkholderia species, two phylogenetically related yet distinct resistance determinants.Semantic proximity Read

Dynamical Responses Predict a Distal Site that Modulates Activity in an Antibiotic Resistance EnzymeSemantic proximity Read

Let's Dance: How Protein Dynamics Drive β-Lactamase Evolution and Antibiotic Resistance?Semantic proximity Read

Evolution of conformational dynamics determines the conversion of a promiscuous generalist into a specialist enzyme.Semantic proximity Read

Gating interactions steer loop conformational changes in the active site of the L1 metallo-β-lactamaseSemantic proximity Read

Evolution of β-lactamases and enzyme promiscuitySemantic proximity Read

Structure and dynamics of <i>Burkholderia pseudomallei</i> OXA-57, a distinctive low efficiency class D β-lactamase with carbapenem-hydrolyzing activitySemantic proximity Read

β-Lactamases and β-Lactamase Inhibitors in the 21st CenturySemantic proximity Read

Exploring the Role of the Ω-Loop in the Evolution of Ceftazidime Resistance in the PenA β-Lactamase from Burkholderia multivorans, an Important Cystic Fibrosis PathogenSemantic proximity Read

Molecular Dynamics-Derived Descriptor Informs the Impact of Mutation on the Catalytic Turnover Number in Lactonase Across Substrates.Semantic proximity Read

Characterization of ceftazidime resistance mechanisms in clinical isolates of Burkholderia pseudomallei from Australia.Semantic proximity Read

Delving into the Characteristic Features of "Menace" Mycobacterium tuberculosis Homologs: A Structural Dynamics and Proteomics Perspectives.Semantic proximity Read