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Article

Let's Dance: How Protein Dynamics Drive β-Lactamase Evolution and Antibiotic Resistance?

Biochemistry - 18 Nov 2025

Warecki Brenda A, Moreno Diego M, Bonomo Robert A, Vila Alejandro J

Abstract excerpt

β-Lactamases are the major mechanism of antimicrobial resistance to β-lactam antibiotics in Gram-negative bacteria. Continuous exposure to these drugs has resulted in >12,400 known variants due to evolutionary pressure. These enzymes represent a unique model for studying protein evolution, as bacterial survival depends on expressing β-lactamases that inactivate the specific β-lactam antibiotic that the bacterium...

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PMID: 41191476
DOI: 10.1021/acs.biochem.5c00437

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