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Dynamic Profiling of β-Coronavirus 3CL Mpro Protease Ligand-Binding Sites

14 Jun 2021

Abstract excerpt

β-coronavirus (CoVs) alone has been responsible for three major global outbreaks in the 21st century. The current crisis has led to an urgent requirement to develop therapeutics. Even though a number of vaccines are available, alternative strategies targeting essential viral components are required as a backup against the emergence of lethal viral variants. One such target is the main protease (M pro ) that plays...

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PMID: 34124899
DOI: 10.1021/acs.jcim.1c00449

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