Back to search

Article

Structure and dynamics of <i>Burkholderia pseudomallei</i> OXA-57, a distinctive low efficiency class D β-lactamase with carbapenem-hydrolyzing activity

2024-12-23

Abstract excerpt

The Gram-negative bacterium Burkholderia pseudomallei causes the severe disease melioidosis. β-Lactams, including carbapenems, are the primary treatment, but are susceptible to chromosomal β-lactamases, including the class D enzyme OXA-57. Here we show recombinant OXA-57 is active towards penicillins and first-generation cephalosporins, slowly hydrolyzes carbapenems including imipenem and meropenem, but is inacti...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
f7873b63-15e6-5040-a36e-9ff825681f5f
DOI
10.1101/2024.12.23.630153
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Structure and dynamics of <i>Burkholderia pseudomallei</i> OXA-57, a distinctive low efficiency class D β-lactamase with carbapenem-hydrolyzing activityDOI 10.1101/2024.12.23.630153
β-Lactamases and β-Lactamase Inhibitors in the 21st CenturySemantic proximity
Advancements in the fight against globally distributed OXA-48 carbapenemase: evaluating the new generation of carbapenemase inhibitorsSemantic proximity
Exploring the Role of the Ω-Loop in the Evolution of Ceftazidime Resistance in the PenA β-Lactamase from Burkholderia multivorans, an Important Cystic Fibrosis PathogenSemantic proximity
A general reaction mechanism for carbapenem hydrolysis by mononuclear and binuclear metallo-β-lactamasesSemantic proximity
QPX7728, An Ultra-Broad-Spectrum B-Lactamase Inhibitor for Intravenous and Oral Therapy: Overview of Biochemical and Microbiological CharacteristicsSemantic proximity
Insights into β-lactamases from Burkholderia species, two phylogenetically related yet distinct resistance determinants.Semantic proximity
Crystal structure of the carbapenemase OXA-24 reveals insights into the mechanism of carbapenem hydrolysisSemantic proximity
Structural Characterization of the Type IV Secretion System in <i>Brucella melitensis</i> for Virtual Screening-Based Therapeutic TargetingSemantic proximity
Modeling of GyrA, MexB, FtsI, AtpD Protein Variants In Multidrug Resistant <i>Acinetobacter baumannii</i>Semantic proximity
Biochemical, structural, and computational studies of a γ-carbonic anhydrase from the pathogenic bacterium Burkholderia pseudomalleiSemantic proximity
Molecular Basis of Selective Inhibition and Slow Reversibility of Avibactam against Class D Carbapenemases: A Structure-Guided Study of OXA-24 and OXA-48Semantic proximity
Dynamically chiral phosphonic acid-type metallo-β-lactamase inhibitorsSemantic proximity
Select a neighboring publication to make it the new centre.