Article
Evolution of conformational dynamics determines the conversion of a promiscuous generalist into a specialist enzyme.
Molecular biology and evolution - 1 Jan 2015
Zou Taisong, Risso Valeria A, Gavira Jose A, Sanchez-Ruiz Jose M, Ozkan S Banu
Abstract excerpt
β-Lactamases are produced by many modern bacteria as a mechanism of resistance toward β-lactam antibiotics, the most common antibiotics in use. β-Lactamases, however, are ancient enzymes that originated billions of years ago. Recently, proteins corresponding to 2- to 3-Gy-old Precambrian nodes in the evolution of Class A β-lactamases have been prepared and shown to be moderately efficient promiscuous catalysts,...
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