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Article

Evolutionary study of metallo-β-lactamase IMP-1 reveals a specific allosteric network mediated by distal mutations.

Journal of inorganic biochemistry - 1 Aug 2026

Dong Xiao-Ting, Dong Yu-Xuan, Wang Kun, Li Ke-Wei, Cao Hui-Ling, Bian Liu-Jiao

Abstract excerpt

Metallo-β-lactamases (MβLs) are a large contributor to antibiotic resistance. To elucidate how MβLs have evolved with the introduction and use of antibiotics, the mutations and evolution of IMP-1 from Pseudomonas aeruginosa were investigated in media with continuous and discontinuous cephalothin (CEF) concentration gradients. The results revealed 6-point mutations, K160R, G165V, A179V, K206T, K214R, and K214E....

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Allosteric Regulation
Bacterial Proteins
beta-Lactamases
Catalytic Domain
Evolution, Molecular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Microbial Sensitivity Tests

Molecular Dynamics Simulation

Pseudomonas aeruginosa

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PMID: 41996979
DOI: 10.1016/j.jinorgbio.2026.113335

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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