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Article

Sex differences in metabolic phenotype and hypothalamic inflammation in the 3xTg-AD mouse model of Alzheimer's disease.

Biology of sex differences - 9 Aug 2023

Robison Lisa S, Gannon Olivia J, Salinero Abigail E, Abi-Ghanem Charly, Kelly Richard D, Riccio David A, Mansour Febronia M, Zuloaga Kristen L

Abstract excerpt

BACKGROUND: Alzheimer's disease (AD) is notably associated with cognitive decline resulting from impaired function of hippocampal and cortical areas; however, several other domains and corresponding brain regions are affected. One such brain region is the hypothalamus, shown to atrophy and develop amyloid and tau pathology in AD patients. The hypothalamus controls several functions necessary for survival,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37559092
DOI: 10.1186/s13293-023-00536-5
PMCID: PMC10410820

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