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Comparative efficacy of the novel diarylquinoline TBAJ-587 and bedaquiline against a resistant <i>Rv0678</i> mutant in a mouse model of tuberculosis

2020-11-18

Abstract excerpt

Since its conditional approval in 2012, bedaquiline (BDQ) has been a valuable tool for treatment of drug-resistant tuberculosis. More recently, a novel short-course regimen combining BDQ with pretomanid and linezolid won approval to treat highly drug-resistant tuberculosis. Clinical reports of emerging BDQ resistance have identified mutations in Rv0678 that de-repress the expression of the MmpL5/MmpS5 efflux tran...

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Literature Corpus work
d45c40ce-ff22-5732-aad0-049bd6b6a8e5
DOI
10.1101/2020.11.17.387977
Open publication

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