Article
Bedquiline Resistance Mutations: Correlations with Drug Exposures and Impact on the Proteome in M. tuberculosis.
Antimicrobial agents and chemotherapy - 18 Jul 2023
Xu Jian, Li Dongshuo, Shi Jinghua, Wang Bin, Ge Fei, Guo Zhenyong, Mu Xiaopan, Nuermberger Eric, Lu Yu
Abstract excerpt
Bedaquiline (BDQ) is an effective drug for the treatment of drug-resistant tuberculosis. Mutations in atpE, which encodes the target of BDQ, are associated with large increases in MICs. Mutations in Rv0678 that derepress the transcription of the MmpL5-MmpS5 efflux transporter are associated with smaller increases in MICs. However, Rv0678 mutations are the most common mutations that are associated with BDQ...
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