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Article

Efficacy of macozinone in mice with genetically diverse susceptibility to Mycobacterium tuberculosis infection.

Microbes and infection - 1 Jan 2000

Nikonenko Boris, Logunova Nadezhda, Egorova Anna, Kapina Marina, Sterzhanova Natalia, Bocharova Irina, Kondratieva Elena, Riabova Olga, Semyonova Lyudmila, Makarov Vadim

Abstract excerpt

Host heterogeneity in pulmonary tuberculosis leads to varied responses to infection and drug treatment. The present portfolio of anti-TB drugs needs to be boosted with new drugs and drug regimens. Macozinone, a clinical-stage molecule targeting the essential enzyme, DprE1, represents an attractive option. Mice (I/St, B6, (AKRxI/St)F1, B6.I-100 and B6.I-139) genetically diverse susceptibility to Mycobacterium...

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Identifiers

PMID: 38852904
DOI: 10.1016/j.micinf.2024.105376

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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