Emergence of Rv0678 (mmpR5) mutations mediating resistance to bedaquiline and clofazimine in a liver transplant recipient with rifampicin-susceptible tuberculosis: A case report.

Abstract excerpt

Bedaquiline (Bdq) is a cornerstone therapeutic agent for multidrug- or rifampicin-resistant tuberculosis (MDR/RR-TB), particularly in short-course regimens, and is currently under investigation for potential use in drug-susceptible tuberculosis. However, the emergence of Bdq-resistant TB strains has garnered global concern due to their profound impact on clinical treatment outcomes. Herein, we present the first...

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