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Article

Contribution of telacebec to novel drug regimens in a murine tuberculosis model

2024-06-27

Abstract excerpt

The clinical efficacy of combination drug regimens containing the first generation diarylquinoline (DARQ) bedaquiline in the treatment of multidrug-resistant tuberculosis has validated ATP synthesis as a vulnerable pathway in Mycobacterium tuberculosis . New DARQs in clinical development may be even more effective than bedaquiline, including against emerging bedaquiline-resistant strains. Telacebec (T) is a novel...

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Literature Corpus work
2d262f6b-16af-5dff-ae1c-e63d3643424b
DOI
10.1101/2024.06.27.601059
Open publication

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Contribution of telacebec to novel drug regimens in a murine tuberculosis modelDOI 10.1101/2024.06.27.601059
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