Article

Next-generation diarylquinolines improve sterilizing activity of regimens with pretomanid and the novel oxazolidinone TBI-223 in a mouse tuberculosis model

2023-01-11

Abstract excerpt

<h4>ABSTRACT</h4> A regimen comprised of bedaquiline, pretomanid and linezolid (BPaL) is the first oral 6-month regimen approved by the US Food and Drug Administration and recommended by the World Health Organization for treatment of extensively drug-resistant tuberculosis. We used a well-established BALB/c mouse model of tuberculosis to evaluate the treatment-shortening potential of replacing bedaquiline with ei...

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Literature Corpus work: aab17e6b-cb0e-513a-97e7-7b5fd667ccd2
DOI: 10.1101/2023.01.10.523519

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