Article
DNA-bound structures and mutants reveal abasic DNA binding by APE1 and DNA repair coordination [corrected].
Nature - 27 Jan 2000
Mol C D, Izumi T, Mitra S, Tainer J A
Abstract excerpt
Non-coding apurinic/apyrimidinic (AP) sites in DNA are continually created in cells both spontaneously and by damage-specific DNA glycosylases. The biologically critical human base excision repair enzyme APE1 cleaves the DNA sugar-phosphate backbone at a position 5' of AP sites to prime DNA repair synthesis. Here we report three co-crystal structures of human APE1 bound to abasic DNA which show that APE1 uses a...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.