Article
Base excision repair of oxidative DNA damage: from mechanism to disease.
Frontiers in bioscience (Landmark edition) - 1 Mar 2017
Whitaker Amy M, Schaich Matthew A, Smith Mallory R, Flynn Tony S, Freudenthal Bret D
Abstract excerpt
Reactive oxygen species continuously assault the structure of DNA resulting in oxidation and fragmentation of the nucleobases. Both oxidative DNA damage itself and its repair mediate the progression of many prevalent human maladies. The major pathway tasked with removal of oxidative DNA damage, and hence maintaining genomic integrity, is base excision repair (BER). The aphorism that structure often dictates...
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